Real-world study of effect on liver function of parenterally administered shuxuetong with different doses / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the effect on liver function of parenterally administered Shuxuetong Injection with different doses.</p><p><b>METHOD</b>The study is based on hospital information system (HIS) data. We group the cases by dose: The observation group receive a dose > 6 mL (recommended daily dose), the matched group receive the recommended dose. Chi-square test, logistic regression, logistic regression with propensity score, logistic regression with GBM propensity score were used to find the between group differences in ALT and AST after using parentyerally administered Shuxuetong injection.</p><p><b>RESULT</b>All tests show that there were no significant differences between groups in AST or ALT after we control for confounding factors.</p><p><b>CONCLUSION</b>Based on HIS data, there was no evidence to associate the use of Shuxuetong over the recommended dose and effects on liver function.</p>