MICM classification and prognostic analysis of 80 adolescents with acute lymphoblastic leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 421-424, 2004.
Article
in Zh
| WPRIM
| ID: wpr-291402
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To explore MICM classification and adverse prognostic factors in adolescents with acute lymphoblastic leukemia (ALL).</p><p><b>METHODS</b>The MICM classification, clinical characteristics of 80 adolescents with ALL admitted to our hospital from January 1998 to December 2002 were retrospectively analyzed. Survival data were estimated by the Kaplan-Meier method and the prognostic factors were analyzed with the COX regression model.</p><p><b>RESULTS</b>In the 80 patients, B-ALL and T-ALL accounted for 69.12% and 26.47%, respectively. The percentage of Ph(+)ALL was 18.37% (9/49), and that of hyperdiploidy was 4.08%. Patients at diagnosis with high leukocyte counts (> 50 x 10(9)/L) accounted for 27.94%. Among the 78 cases treated with VDP(L) or CODP(L) regimens, 73 (91.03%) obtained CR in 4 weeks. After a median follow-up of 24 months, the estimated 3-year disease-free survival (DFS) rates of patients receiving chemotherapy or allo-HSCT were (32.55 +/- 16.50)% and (69.58 +/- 8.72)%, respectively (P < 0.05). In COX analysis, high initial leukocyte counts (> 50 x 10(9)/L) and Philadelphia chromosome positivity were adverse prognostic factors for long-term survival.</p><p><b>CONCLUSIONS</b>MICM classification has important clinical and prognostic significance in the risk-directed therapy of adolescents with ALL. The adverse prognostic features for these patients were high leukocyte counts, less incidence of chromosome hyperdiploidy and Ph chromosome positivity.</p>
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
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Therapeutics
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Retrospective Studies
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Risk Factors
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Classification
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Combined Modality Therapy
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Kaplan-Meier Estimate
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Genetics
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Karyotyping
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hematology
Year:
2004
Type:
Article