Identification of Wnt/beta-catenin signal pathway in human prostate cancer cell lines and its significance / 中华男科学杂志
National Journal of Andrology
;
(12): 310-313, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-292381
ABSTRACT
<p><b>OBJECTIVE</b>To determine the Wnt/beta-catenin signal pathway in different human prostate cancer cell lines and explore its role in epithelial-mesenchymal transition (EMT) in human prostate cancer.</p><p><b>METHODS</b>We detected the expressions of beta-catenin, t-GSK3beta and p-GSK3beta in several prostate cancer cell lines (LNCaP, C4, C4-2, C4-2B, IF11, IA8, PC-3 and DU145) with different characteristics of epithelial-mesenchymal transition (EMT) by Western blotting.</p><p><b>RESULTS</b>There were remarkable differences in the expressions of beta-catenin and p-GSK3beta among the cell lines, with beta-catenin and p-GSK3beta highly expressed in LNCaP, C4, C4-2, C4-2B, IF11 and IA8, lowly expressed in PC-3 and DU145, but no difference was observed in the expressions of t-GSK3beta in all the cell lines.</p><p><b>CONCLUSION</b>There are differences in the state of the Wnt/beta-catenin signal pathway among the cell lines with different characters of EMT.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Neoplasms
/
Signal Transduction
/
Cell Line, Tumor
/
Wnt Proteins
/
Beta Catenin
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2009
Type:
Article
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