Classification and regression tree analysis of 154 patients with cancer of unknown primary / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 690-693, 2010.
Article
in Zh
| WPRIM
| ID: wpr-293525
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic factors and their impact on survival of patients with cancer of unknown primary (CUP).</p><p><b>METHODS</b>The clinical and follow up data of 154 CUP patients referred to the Cancer Hospital & Institute, Chinese Academy of Medical Sciences from January 1, 2003 to December 31, 2007 were analyzed. Multivariate analysis of survival was performed using recursive partitioning referred to as classification and regression tree (CART) analysis.</p><p><b>RESULTS</b>The median survival for 154 eligible consecutive CUP patients was 18.2 months, and the 5-year survival rate was 1.3%. CART was performed with an initial split on age of 34, and 5 terminal subgroups were formed. The median survival of the 5 subsets ranged from 5.5 months (younger than 34 years old subgroup) to 61.8 months for patients at age of 34 to 60, with one or two organ sites involved, and non-adenocarcinoma histology subsets.</p><p><b>CONCLUSIONS</b>CART can be used to identify previously unappreciated patient subsets and is a useful method for dissecting complex clinical situations and identifying homogeneous patient populations in clinical practice and future clinical trials.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Bone Neoplasms
/
Neoplasms, Unknown Primary
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Multivariate Analysis
/
Survival Rate
/
Regression Analysis
/
Follow-Up Studies
/
Classification
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2010
Type:
Article