Effect of danshensu, protocatechualdehyde and danshen injection on calcium ion concentration in cytoplasm of human erythrocytes / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the predominant calcium-antagonist components of Danshen injection.</p><p><b>METHOD</b>The effects of danshensu, protocatechualdehyde and Danshen injection on calcium concentration in cytoplasm of erythrocytes were examined in vitro by the fluorescent Ca+ -chelator fura-2.</p><p><b>RESULT</b>Either DS182 or PCAD can decrease in dose-dependent cytosolic free calcium concentration in human erythrocytes. They had additive effect when mixed, which was similar to Danshen injection.</p><p><b>CONCLUSION</b>DS182 and PCAD may be predominant calcium-antagonist components of Danshen injection.</p>