Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea
Allergy, Asthma & Immunology Research
; : 415-420, 2014.
Article
in En
| WPRIM
| ID: wpr-29489
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. This study was carried out to identify the common causative drugs and clinical features of FDE in Korea.METHODS:
We reviewed electronic medical records of all patients diagnosed with FDE from January 2000 to December 2010 at a tertiary hospital in Korea.RESULTS:
A total of 134 cases were diagnosed as FDE. The mean age was 35.9 years (range, 0-82 years) and 69 (51.5%) of the patients were male. The mean duration from the first event to attending hospital was 1.9 years (range, 1-20 years). The mean number of recurrences was 2.6 (1-10), and 72.6% of patients sought medical care after experiencing symptoms twice or more. Four patients (3.1%) needed hospitalization. The most common sites were the upper extremities (47.7%), followed by the lower extremities, face, abdomen, chest, buttocks and perineum. Clear documentation on the causative drugs was available for 38 patients (28.4%), and among these, non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen accounted for 71.1% of cases, and antibiotics accounted for 15.8%. Eighty patients (59.7%) underwent active treatment for FDE, and topical steroids were most frequently prescribed (43.3%), with systemic steroids used in 11.2% of patients.CONCLUSIONS:
NSAIDs and acetaminophen were the main causative agents of FDE, however, the causative agents were not assessed in 25% of patients.Key words
Full text:
1
Index:
WPRIM
Main subject:
Perineum
/
Recurrence
/
Steroids
/
Thorax
/
Buttocks
/
Anti-Inflammatory Agents, Non-Steroidal
/
Hyperpigmentation
/
Drug Eruptions
/
Lower Extremity
/
Upper Extremity
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Allergy, Asthma & Immunology Research
Year:
2014
Type:
Article