Pharmacokinetics of hylotelephin in Beagle dogs / 药学学报
Acta Pharmaceutica Sinica
; (12): 680-683, 2006.
Article
in Zh
| WPRIM
| ID: wpr-294959
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the pharmacokinetics of hylotelephin in Beagle dogs and obtain the main pharmacokinetic parameters.</p><p><b>METHODS</b>An HPLC method with UV detection was developed to study the pharmacokinetics of hylotelephin in dogs by joining an internal standard (anthracene). Benzoyl chloride was used to the pre-column derivatization of hylotelephin and methanol-water (64:36) was used as the mobile phase. According to the 3P97 pharmacokinetic program, the main parameters were calculated.</p><p><b>RESULTS</b>The hylotelephin pharmacokinetics conforms to a two-compartment open model after a single iv dose of hylotelephin 10.6 or 21.3 mg x kg(-1) in Beagle dogs. The parameters of two groups were as follows: T(1/2) alpha were 2.3 and 2.1 min, T(1/2) beta were 1.9 and 2.0 h, K12 were 0. 12 and 0.11 min, K21 were 0.17 and 0.21 min, K10 were 0.011 and 0.0094 min, Vc were 0.54 and 0.54 L x kg(-1), AUC were 1.8 and 4.1 g x min x L(-1), CL were 0.0048 and 0.0056 L x kg(-1) x min(-1), MRT were 2.10 and 2.4 h, respectively.</p><p><b>CONCLUSION</b>The pharmacokinetics of hylotelephin after iv administration showed a rapid distribution and elimination process in Beagle dogs and was of first order kinetics.</p>
Full text:
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Index:
WPRIM
Main subject:
Antiviral Agents
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Plants, Medicinal
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Spectrophotometry, Ultraviolet
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Pharmacokinetics
/
Molecular Structure
/
Chemistry
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Chromatography, High Pressure Liquid
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Area Under Curve
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Crassulaceae
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Heterocyclic Compounds, 3-Ring
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article