Effects of intracoronary autologous bone marrow mononuclear cells transplantation in patients with anterior myocardial infarction / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 103-106, 2006.
Article
in Zh
| WPRIM
| ID: wpr-295367
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the efficacy of intracoronary transfer of autologous bone marrow mononuclear cells (ABMMNCs) to patients with myocardial infarction (MI) on left ventricular function and myocardial perfusion.</p><p><b>METHODS</b>Thirty-five patients with MI (> 4 weeks) were enrolled in this prospective, open-labeled study (20 patients in cell transplantation group; 15 patients in control group). All patients were treated by standard drug therapy and percutaneous coronary intervention (PCI). Baseline and 3 months follow-up evaluations included complete clinical and laboratory examinations, six minutes walk test, echocardiography, Dual-isotope simultaneous acquisition single photon emission computed tomography (DISA-SPECT) and cardiac magnetic resonance imaging (MRI).</p><p><b>RESULTS</b>Baseline parameters were similar between the two groups. NYHA classification and six minutes walk test at 3 months follow-up were also similar between the two groups. However, left ventricular ejection fraction (LVEF) determined by echocardiography and DISA-SPECT was significantly higher; regional wall motion measured by echocardiography and cardiac MRI, myocardial viability and myocardial perfusion in the infarct zone assessed by DISA-SPECT were all significantly improved than before transplantation and than that in control group at 3 months follow-up.</p><p><b>CONCLUSIONS</b>Our results indicate that intracoronary transplantation of ABMMNCs could improve the left ventricular systolic function and beneficially affect myocardial perfusion up to 3 months post transplantation in patients with myocardial infarction.</p>
Full text:
1
Index:
WPRIM
Main subject:
General Surgery
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Therapeutics
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Transplantation, Autologous
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Tomography, Emission-Computed, Single-Photon
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Prospective Studies
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Follow-Up Studies
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Ventricular Function, Left
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Bone Marrow Transplantation
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Methods
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Myocardial Infarction
Type of study:
Observational_studies
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Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2006
Type:
Article