A new human leukocyte antigen class I allele, HLA- B*52:11 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 712-715, 2011.
Article
in Zh
| WPRIM
| ID: wpr-295547
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify and confirm a novel HLA allele.</p><p><b>METHODS</b>A new human leukocyte antigen class I allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).</p><p><b>RESULTS</b>The novel HLA-B*52 allele was identical to B*52:01:01 with an exception of one base substitution at position 583 of exon 3 where a C was changed to T resulting in codon 195 changed from CAC(H) to TAC(Y).</p><p><b>CONCLUSION</b>A new HLA class I allele, B*52:11, is identified, and is named officially by the WHO Nomenclature Committee.</p>
Full text:
1
Index:
WPRIM
Main subject:
Molecular Sequence Data
/
Base Sequence
/
HLA-B Antigens
/
Sequence Alignment
/
Amino Acid Sequence
/
Sequence Analysis, DNA
/
Alleles
/
Genetics
/
Genotype
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article