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Expression of EpCAM and E-cadherin in papillary thyroid carcinoma and its clinicopathologic significance / 中华病理学杂志
Chinese Journal of Pathology ; (12): 189-194, 2015.
Article in Zh | WPRIM | ID: wpr-298081
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of EpCAM and E-cadherin in papillary thyroid carcinoma and to analyze its correlation with various clinicopathologic parameters.</p><p><b>METHODS</b>Immunohistochemical study for EpCAM and E-cadherin was carried out in 91 cases of papillary thyroid carcinoma. Twenty-four cases of papillary hyperplasia of thyroid were used as controls.</p><p><b>RESULTS</b>In all of the 24 cases of papillary hyperplasia, EpCAM was located on the cell membrane, while in the 91 cases of papillary thyroid carcinoma studied, EpCAM was located within the cytoplasm, with 36.3% (33/91) showing nuclear localization as well. In all the papillary hyperplasia cases studied, E-cadherin showed membranous expression. E-cadherin expression was reduced in 84.6% (77/91) of papillary thyroid carcinoma, as compared with the surrounding native thyroid parenchyma. Amongst the 33 cases of papillary thyroid carcinoma which showed nuclear localization of EpCAM, 30 cases also showed reduced E-cadherin expression. There was a positive correlation between nuclear expression of EpCAM and loss of E-cadherin expression (P = 0.000; Spearman correlation coefficient = 0.857). Nuclear expression of EpCAM correlated with follicular variant of papillary thyroid carcinoma and presence of extrathyroidal extension ( P = 0.037 and 0.033, respectively). Loss of E-cadherin expression correlated with age of patients and presence of lymph node metastasis (P = 0.018 and 0.010, respectively).</p><p><b>CONCLUSIONS</b>E-cadherin expression is reduced in papillary thyroid carcinoma, as compared with native thyroid parenchyma and papillary hyperplasia. Papillary thyroid carcinoma shows loss of EpCAM membranous expression and increased cytoplasmic/nuclear accumulation. Detection of these two markers may provide a valuable reference in defining the biologic behaviors of papillary thyroid carcinoma, including extrathyroidal extension and lymph node metastasis.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pathology / Thyroid Neoplasms / Carcinoma, Papillary / Cadherins / Cell Adhesion Molecules / Cell Membrane / Cytoplasm / Epithelial Cell Adhesion Molecule / Lymphatic Metastasis / Metabolism Limits: Humans Language: Zh Journal: Chinese Journal of Pathology Year: 2015 Type: Article
Full text: 1 Index: WPRIM Main subject: Pathology / Thyroid Neoplasms / Carcinoma, Papillary / Cadherins / Cell Adhesion Molecules / Cell Membrane / Cytoplasm / Epithelial Cell Adhesion Molecule / Lymphatic Metastasis / Metabolism Limits: Humans Language: Zh Journal: Chinese Journal of Pathology Year: 2015 Type: Article