Studies on extraction of Ligusticum chuanxiong in Hongye Xintong soft capsule by super critical fluid extraction / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 161-164, 2009.
Article
in Zh
| WPRIM
| ID: wpr-298443
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the rationality of extraction prosess for the Ligusticum chuanxiong in Hongye Xintong Soft Capsule by super critical fluid extraction(SFE).</p><p><b>METHOD</b>Conditions for the extraction were optimized by orthogonal experimental design as guided by the extraction rate and content of ligustilid in the extract; Combined with the experiment of rats ligated the left coronary artery, the two compounds containing different extracts (steam distillation and SFE) were compared to determine the extraction prosess.</p><p><b>RESULT</b>The best extraction conditions were established as following pressure 30 MPa, temperature 50 degrees C, extracting time 4 h, separate pressure 10 MPa. separate temperature 40 degrees C. Compared with steam distillation, the compound containing SFE extract showed stronger protective effects on rats ligated the left coronary artery.</p><p><b>CONCLUSION</b>Super critical fluid can extract active ingredients in Ligusticum chuanxiong effectively.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Pressure
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Temperature
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Time Factors
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Capsules
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Drugs, Chinese Herbal
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Water
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Chemistry
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Coronary Vessels
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Chromatography, Supercritical Fluid
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article