Preparation and release characterization in vitro of pulsed-release tablets of compound Danshen / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 30-34, 2009.
Article
in Zh
| WPRIM
| ID: wpr-298471
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare pulsed-release tablet (PTS) according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen.</p><p><b>METHOD</b>PTS were achieved by coating the core which contains drugs, CMS-Na, lactose, succinic acid and MCC with separation layer (Eudragit RL), swelling layer (HPMC E5), and controlled-release membrane (Eudragit RS-RL-EC).</p><p><b>RESULT</b>The results of in vitro experiments showed that no difference was observed among the profiles of Danshensu, protocatechuic aldehyde, ginsenoside Rg1, Rb1, notoginsenoside R1 release from the two-step release system. And it indicated that swelling was the basis and prerequisite for drug release from PTS, and the diffusion, organic acid-induced, and osmotic pumping mechanism were involved in drug release, but the latter they were the dominant factors.</p><p><b>CONCLUSION</b>Successfully obtained the PTS of a certain lag-time behind the rapid release which indicate that after bed time administration of such device, the drug plasma concentration-time curve CAN meet the requirements of chronotherapy of cardiovascular disease.</p>
Full text:
1
Index:
WPRIM
Main subject:
Osmosis
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Tablets
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Time Factors
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Benzaldehydes
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Drugs, Chinese Herbal
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Catechols
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Chemistry
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Chromatography, High Pressure Liquid
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Drug Delivery Systems
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Coronary Disease
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article