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Transhepatic arterial chemoembolization with gemcitabine and carboplatin for the treatment of stage III hepatocellular carcinoma / 中华肿瘤杂志
Zhonghua zhong liu za zhi ; (12): 623-625, 2007.
Article in Zh | WPRIM | ID: wpr-298534
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficiency and safety of transhepatic arterial chemoembolization (TACE) with gemcitabine and carboplatin for the treatment of stage III hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Sixty-one HCC patients were treated by TACE. During TACE, At first, intra-arterial infusion of carboplatin 300 mg/m2, then gemcitabine 1000 mg/m2 with 5-30 ml of ultra-lipoidal iodide oil emulsion was used for arterial embolization. The toxicity and hepatic damage were observed according to WHO anticancer drug toxicity criteria and Child-Pugh classification criteria, respectively. The survival time was also observed during follow-up.</p><p><b>RESULTS</b>The blood toxicity was bone marrow suppression presented as grade I leucopenia in 39.3%, grade II in 29.5%, grade III-IV in 18.0%. Grade II-III nausea and vomiting developed in 96.8% of the patients. Hepatic function damage became aggravated in 16 patients from A to B class, in 2 from A to C class, and in 6 from B to C class according to Child-Pugh classification criteria. The median survival time was 20 months with a range of 5 to 3 5 months.</p><p><b>CONCLUSION</b>Transhepatic arterial chemoembolization using carboplatin and mixture of gemcitabine with ultra-lipoidal iodide oil emulsion is safe and effective in the management of stage III hepatocellular carcinoma. This regimen can also improve their quality of life.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pathology / Quality of Life / Therapeutics / Blood / Remission Induction / Survival Rate / Follow-Up Studies / Carboplatin / Chemoembolization, Therapeutic / Carcinoma, Hepatocellular Type of study: Observational_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male Language: Zh Journal: Zhonghua zhong liu za zhi Year: 2007 Type: Article
Full text: 1 Index: WPRIM Main subject: Pathology / Quality of Life / Therapeutics / Blood / Remission Induction / Survival Rate / Follow-Up Studies / Carboplatin / Chemoembolization, Therapeutic / Carcinoma, Hepatocellular Type of study: Observational_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male Language: Zh Journal: Zhonghua zhong liu za zhi Year: 2007 Type: Article