Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 792-796, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298686
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension.</p><p><b>METHODS</b>After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95-114 mmHg and seated systolic blood pressure < 180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks.</p><p><b>RESULT</b>All the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide.</p><p><b>CONCLUSION</b>The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulfonamides
/
Prazosin
/
Angiotensin-Converting Enzyme Inhibitors
/
Calcium Channel Blockers
/
Treatment Outcome
/
Classification
/
Doxazosin
/
Adrenergic beta-Antagonists
/
Blood Pressure Monitoring, Ambulatory
/
Therapeutic Uses
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2007
Type:
Article
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