Determination of intrinsic alliin dissolution rates with fiber-optic sensing process analysis / 药学学报
Acta Pharmaceutica Sinica
; (12): 1475-1478, 2014.
Article
in Zh
| WPRIM
| ID: wpr-299109
Responsible library:
WPRO
ABSTRACT
The apparatus for intrinsic dissolution test recorded in United States Pharmacopeia (USP) integrating with fiber-optic drug dissolution test system (FODT) were used to real-time monitor intrinsic dissolution processes of alliin in four media which were water, solution of HCl with pH 1.2, buffer solution of acetate with pH 4.5, and buffer solution of phosphate with pH 6.8. The intrinsic dissolution rate (IDR) and the similarity factor (f2) of two intrinsic dissolution curves with two apparatuses were calculated. The IDR values of alliin with rotating disk system were 28.1.3, 33.55, 28.38 and 30.95 mg x cm(-2) x min(-1) in four media, respectively. And the IDR values of alliin with stationary disk system were 44.16, 47.07, 45.11 and 51.34 mg x cm(-2) x min(-1), respectively. The similarity factors were 56.42, 50.75, 40.30 and 40.64, respectively. The results showed that the intrinsic alliin dissolution rates were much greater than 1 mg x cm(-2) x min(-1). It inferred that alliin dissolution would not be the rate limiting step to absorption.
Full text:
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Index:
WPRIM
Main subject:
Solubility
/
Chemistry
/
Cysteine
/
Fiber Optic Technology
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article