Pulmonary function testing in Chinese patients with pulmonary arterial hypertension / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 3-6, 2008.
Article
in Zh
| WPRIM
| ID: wpr-299510
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the diagnostic value of pulmonary function testing in Chinese patients with known pulmonary arterial hypertension (PAH) without history of lung/heart valve diseases.</p><p><b>METHODS</b>Pulmonary function testing was performed in 41 PAH patients diagnosed by right heart catheterization and in 17 healthy controls.</p><p><b>RESULTS</b>Normal pulmonary function testing results were found in 5 PAH patients (12.2%). Total lung capacity, vital capacity and FEV1 were significantly decreased in PAH patients [(80.27 +/- 11.46)% vs. (94.24 +/- 6.82)%; (79.09 +/- 14.89)% vs. (97.35 +/- 9.51)%; (75.40 +/- 16.58)% vs. (95.12 +/- 12.01)%, respectively, all P < 0.001], the ratio of residual volume/total lung capacity was significantly increased [(117.67 +/- 25.73)% vs. (93.39 +/- 10.87)%, P < 0.001]; FEV1/FVC and maximal expiratory flow of 25% to 75% tended to be lower (-6.0% and -19.4%, P = 0.21 and 0.09) while DLCO and DLCO/VA were significantly decreased by 36.6% and 29.8% (P < 0.001) compared with healthy controls.</p><p><b>CONCLUSIONS</b>Increased peripheral airway obstruction and normal lung resistance were found in these PAH patients. Normal pulmonary function testing results could not rule out the diagnosis of PAH.</p>
Full text:
1
Index:
WPRIM
Main subject:
Respiratory Function Tests
/
Case-Control Studies
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Pulmonary Diffusing Capacity
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Vital Capacity
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Forced Expiratory Volume
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Cross-Sectional Studies
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Hypertension, Pulmonary
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Lung
Type of study:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2008
Type:
Article