The evaluation of the diagnosis and treatment of 32 cases with ectopic ACTH syndrome / 中华外科杂志
Chinese Journal of Surgery
; (12): 583-586, 2004.
Article
in Zh
| WPRIM
| ID: wpr-299897
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate and discuss the diagnosis and treatment of ectopic ACTH syndrome.</p><p><b>METHODS</b>Clinical data of 32 cases of ectopic ACTH syndrome, recruited from January 1990 to April 2003 in our hospital, was analyzed.</p><p><b>RESULTS</b>All of the 32 cases presented with clinical and biochemical evidences of Cushing's syndrome. Ten cases were definitively diagnosed as ectopic ACTH syndrome by finding ectopic tumors; 4 cases were highly suspected as ectopic ACTH by blood sampling from femoral vein and infra-petrosal vein and 18 cases were suspected as ectopic ACTH by imaging examinations. Fifteen cases (47%), without identified source of ectopic hormone, were treated with bilateral or unilateral total adrenalectomy, with 1-year survival rate of 60%. Seven cases (22%), with possible source of ectopic hormone, underwent no intervention, with 1-year survival rate of 0. Ten cases underwent radical resection of tumor, 6 of which were bronchial carcinoids and 4 of which were thymic carcinoids, with 1-year survival rate of 60%.</p><p><b>CONCLUSION</b>It is very difficult to localize the tumor of ectopic ACTH syndrome patients. Bilateral adrenalectomy followed by hormonal replacement is effective for most of the patients without identifying source of ectopic hormone.</p>
Full text:
1
Index:
WPRIM
Main subject:
Therapeutics
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ACTH Syndrome, Ectopic
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Survival Rate
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Follow-Up Studies
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Mortality
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Combined Modality Therapy
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Adrenalectomy
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Diagnosis
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Methods
Type of study:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2004
Type:
Article