Synthesis and antibacterial activity of 2-(3-pyridyl)-5-((5-aryl-1,3,4-oxadiazol-2-yl) methylenethio)-1,3,4-oxadiazoles / 药学学报
Acta Pharmaceutica Sinica
; (12): 263-265, 2004.
Article
in Zh
| WPRIM
| ID: wpr-301100
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>Studies on synthesis and antibacterial activity of new heterocycles.</p><p><b>METHODS</b>The cyclocondensation of [(3-pyridyl)-1,3,4-oxadiazol-2-yl] thio acetic acid with various aroyl hydrazines in the presence of POCl3 and xylene gave the corresponding titled compounds, and the in vitro antibacterial activity was primarily evaluated by the method of cupplate diffusion solution.</p><p><b>RESULTS</b>Sixteen novel titled compounds were synthesized, their structures were confirmed by IR, 1HNMR, MS and elemental analysis. Biological screening results demonstrated that most of the compounds prepared displayed potential antibacterial activity.</p><p><b>CONCLUSION</b>Oxadiazoles incorporting pyridyl oxadiazole ring may be usefully antibacterial candidate drugs.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oxadiazoles
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Pharmacology
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Proteus vulgaris
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Staphylococcus aureus
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Chemistry
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Escherichia coli
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Anti-Bacterial Agents
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article