Study on distribution of safflor yellow A in tissues of mice / 药学学报

ABSTRACT

<p><b>AIM</b>To study the distributive character of safflor yellow A in mice.</p><p><b>METHODS</b>A RP-HPLC method for the determination of safflor yellow A in tissues was established and applied to determine safflor yellow A in biological samples.</p><p><b>RESULTS</b>After iv injection of Safflor yellow A in mice, the AUC of safflor yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain.</p><p><b>CONCLUSION</b>The distribution of safflor yellow A in the body is abroad and the speed of its process is swift.</p>