Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 360-363, 2002.
Article
in En
| WPRIM
| ID: wpr-302011
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of extracellular signal-regulated kinase (ERK) and its relationship with clinicopathological characteristics of breast cancer as well as the effect of preoperative chemotherapy on ERK expression.</p><p><b>METHODS</b>Expression of ERK-1 and ERK-2 protein was examined by Western blot in the breast cancer and normal breast (control) tissue of 48 patients, of whom 8 had received preoperative chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR), with distribution of ERKs protein detected by immunohistochemical method.</p><p><b>RESULTS</b>Expression of ERK-1 and ERK-2 protein was increased in tumor specimen as compared with control tissue (P < 0.01). A positive correlation was observed between ERK-1 and ERK-2 (r = 0.457, P < 0.01). Protein level of ERK-1 and ERK-2 was higher in stage III patients than in stage I and stage II patients (P < 0.05). Expression of both ERK-1 and ERK-2 in the carcinoma tissue was decreased in patients who had received preoperative chemotherapy of 5'-DFUR. ERK-1 and ERK-2 proteins were mainly located in the cytoplasm.</p><p><b>CONCLUSION</b>The hyperexpression of ERK may play an important role in the initiation and development of human breast cancer. Preoperative chemotherapy of 5'-DFUR is able to partially inhibit ERK expression.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Breast Neoplasms
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Classification
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Floxuridine
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinases
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Therapeutic Uses
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Mitogen-Activated Protein Kinase 3
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Drug Therapy
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Neoplasm Staging
Limits:
Female
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Humans
Language:
En
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article