Expression of G-CSFR IV isoform in adult acute myeloid leukemia and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 899-902, 2014.
Article
in Zh
| WPRIM
| ID: wpr-302376
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the expression of granulocyte colony-stimulating factor receptor IV(G-CSFR IV) in adult acute leukemia patients and its clinical significance. The bone marrow hematopoietic stem cells from healthy persons were used as controls. The real-time RT-PCR was used to determine the expression level of G-CSFR I-IV in 99 AML, 34 ALL patients and 19 healthy persons. The results showed that the relative expression level of G-CSFR IV/G-CSFR I in AML patients was obviously elevated, as compared with that in ALL patients and controls, while the relative expression level of G-CSFR IV/G-CSFR I in ALL patients showed no statistical difference from controls. The analysis of clinical features and chemotherapeutic efficacy demonstrated that the clinical remission rate in patients with high expression of G-CSFR IV/G-CSFR I was lower than that in patients with low expression. The relative expression level of G-CSFR IV/G-CSFR I was not related with risk stratification from sex, age, blast ratio, FAB typing, chromosome and fusion gene. It is concluded that the abnormal high expression of G-CSFR IV relates with poor prognosis of AML.
Full text:
1
Index:
WPRIM
Main subject:
Hematopoietic Stem Cells
/
Leukemia, Myeloid, Acute
/
Case-Control Studies
/
Receptors, Granulocyte Colony-Stimulating Factor
/
Protein Isoforms
/
Metabolism
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2014
Type:
Article