Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanoparticles for oral administration in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 463-466, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-302785
ABSTRACT
<p><b>AIM</b>To study the preparation of hydroxypropyl methylcellulose phthalate (HPMCP) nanoparticles and compare its pharmacokinetic characteristics with Neoral.</p><p><b>METHODS</b>HPMCP nanoparticles loaded cyclosporine A were prepared by solvent-nonsolvent method. CyA-HP50 nanoparticles, CyA-HP55 nanoparticles and Neoral were orally administered at the dosage of 15 mg x kg(-1) to rats. The CyA concentration in blood were determined by HPLC. Pharmacokinetic parameters were calculated by 3P97 program.</p><p><b>RESULTS</b>The concentration-time data of the three preparations were best fit by two compartment model. The relative bioavailability of CyA-HP50 and CyA-HP55 nanoparticles calculated by the AUC0-72 were 82.3% and 119.6%, bioequivalent to the reference of Neoral. The relative bioavailability of CyA-HP55 nanoparticles was 145.3% of CyA-HP50 nanoparticles.</p><p><b>CONCLUSION</b>CyA HPMCP nanoparticles could be prepared easily and reproducibly. It was found that the oral absorption of CyA can be increased by using the HPMCP nanoparticles.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Pharmacokinetics
/
Biological Availability
/
Administration, Oral
/
Cyclosporine
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Nanostructures
/
Immunosuppressive Agents
/
Methylcellulose
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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