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Research progress on hypoglycemic effect and its mechanism of action of medicinal fungal polysaccharides / 中国中药杂志
Article in Zh | WPRIM | ID: wpr-305327
Responsible library: WPRO
ABSTRACT
Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. Medicinal fungal polysaccharides, as water-soluble macromolecular substances with low toxicity, exhibit diversified pharmacological actions such as immune regulation, anti-tumor, antivirus, antioxidant, anti-aging, hypoglycemic effect and improving liver and kidney function. In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and β cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of α-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation. Therefore, the hypoglycemic activity and its mechanisms of action of medicinal fungal polysaccharides showed characteristics of multiple effects, multi-target, and multi-pathway regulation. These finding suggest that medicinal fungal polysaccharides are a promising source for the development of discovery of anti-diabetic agent.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pharmacology / Insulin Resistance / Oxidative Stress / Insulin-Secreting Cells / Carbohydrate Metabolism / Fungal Polysaccharides / Hypoglycemic Agents Limits: Animals / Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Insulin Resistance / Oxidative Stress / Insulin-Secreting Cells / Carbohydrate Metabolism / Fungal Polysaccharides / Hypoglycemic Agents Limits: Animals / Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article