Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia / 中华男科学杂志
National Journal of Andrology
; (12): 615-618, 2011.
Article
in Zh
| WPRIM
| ID: wpr-305834
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of tamoxifen (TMX) combined with coenzyme Q10 (CoQ10) on idiopathic oligoasthenospermia.</p><p><b>METHODS</b>A total of 183 patients with idiopathic oligoasthenospermia were randomly divided into a TMX + CoQ10 group (n = 63), a TMX group (n = 61) and a CoQ10 group (n = 59). At the end of 3 and 6 months of treatment, semen analyses and hormone tests were performed, and the results were compared with those obtained before the treatment.</p><p><b>RESULTS</b>Compared with the pre-treatment results, the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) and sperm concentration were significantly elevated in the TMX + CoQ10 and TMX groups (P < 0.05), but showed no significant difference in the CoQ10 group (P > 0.05); sperm motility and morphologically normal sperm were increased significantly in the TMX + CoQ10 and CoQ10 groups (P < 0.05), and slightly in the TMX group but with no statistically significant difference (P > 0.05).</p><p><b>CONCLUSION</b>Tamoxifen combined with CoQ10 can significantly improve sperm concentration, motility and morphology in patients with idiopathic oligoasthenospermia.</p>
Full text:
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Index:
WPRIM
Main subject:
Oligospermia
/
Tamoxifen
/
Ubiquinone
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Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
Limits:
Adult
/
Humans
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Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2011
Type:
Article