Identification of estrogen-associated intrinsic aging genes in Chinese Han female skin by cDNA microarray technology / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 364-373, 2011.
Article
in English
| WPRIM
| ID: wpr-306850
ABSTRACT
<p><b>OBJECTIVE</b>Estrogens play an important role in intrinsic skin aging. The associated changes in global gene expression are poorly understood.</p><p><b>METHODS</b>We used the Illumina microarray platform to obtain comprehensive gene expression profiles in female Chinese Han skin, and confirmed the data by quantitative real-time PCR (Q-RT-PCR).</p><p><b>RESULTS</b>We found 244 genes significantly related to estrogen-associated intrinsic skin aging, and some of these genes were confirmed by Q-RT-PCR. We also performed functional analysis by both Gene Ontology annotation and enrichment of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways database. The functional analysis revealed 11 biological pathways (including the KEGG pathways, the mitogen-activated protein kinase signaling pathway and metabolic pathways), that were associated with multiple cellular functions which may be involved in intrinsic skin aging.</p><p><b>CONCLUSION</b>This study suggests that estrogen-associated intrinsic skin aging is a complicated biological process involving many genes and pathways.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Skin
/
Aging
/
Menopause
/
RNA
/
China
/
Gene Expression Regulation
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Estrogens
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2011
Type:
Article
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