Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2079-2082, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-307640
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of ferment powder caterpillar fungus on cytochrome P450 isozymes CYP1A2, CYP3A4 and CYP2E1.</p><p><b>METHOD</b>The methods of Cocktail probe drugs were used. The rats were randomly divided into two groups. One group were given ferment powder caterpillar fungus once daily orally for ten days. Another group received orally normal saline one daily as the blank control. After ten days of treatment, the rats were given probe drugs of coffine, dapsone and chlorzoxazone and the blood was taken out by femoral catheterization. The plasma concentration of probe drugs were determined by HPLC. Data of plasma drug level-time were disposed with DAS Ver 2.0.</p><p><b>RESULT</b>The metabolism of caffeine and dapsone speeded up after receiving ferment powder caterpillar fungus, but the metabolism of chlorzoxazone was hardly changed.</p><p><b>CONCLUSION</b>It suggested that ferment powder caterpillar fungus tended to be the inducer of CYP1A2 and CYP3A4. But the CYP2E1 was hardly affected.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Caffeine
/
Drugs, Chinese Herbal
/
Random Allocation
/
Chlorzoxazone
/
Rats, Wistar
/
Cytochrome P-450 Enzyme System
/
Dapsone
/
Fermentation
/
Cytochrome P-450 Enzyme Inhibitors
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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