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Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1262-1264, 2003.
Article in English | WPRIM | ID: wpr-311704
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effectiveness of small interfering RNA (siRNA) on inhibiting severe acute respiratory syndrome (SARS)-associated coronavirus replication, and to lay bases for the future clinical application of siRNA for the treatment of viral infectious diseases.</p><p><b>METHODS</b>Vero-E6 cells was transfected with siRNA before SARS virus infection, and the effectiveness of siRNA interference was evaluated by observing the cytopathic effect (CPE) on Vero-E6 cells.</p><p><b>RESULTS</b>Five pairs of siRNA showed ability to reduce CPE dose dependently, and two of them had the best effect.</p><p><b>CONCLUSION</b>siRNA may be effective in inhibiting SARS-associated coronavirus replication.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Virus Replication / Vero Cells / Transfection / Chlorocebus aethiops / RNA, Small Interfering / Severe acute respiratory syndrome-related coronavirus Limits: Animals Language: English Journal: Chinese Medical Journal Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Virus Replication / Vero Cells / Transfection / Chlorocebus aethiops / RNA, Small Interfering / Severe acute respiratory syndrome-related coronavirus Limits: Animals Language: English Journal: Chinese Medical Journal Year: 2003 Type: Article