Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography combined with inflammatory factors for detecting atherosclerotic plaques in rabbits / 南方医科大学学报
Journal of Southern Medical University
; (12): 1324-1328, 2014.
Article
in Zh
| WPRIM
| ID: wpr-312579
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility of Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography (USPIO-MRA) combined with interleukin-6 (IL-6) and IL-10 detection for detecting atherosclerotic plaques in rabbits.</p><p><b>METHODS</b>Twenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10.</p><p><b>RESULTS</b>The rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups.</p><p><b>CONCLUSION</b>USPIO-MRA combined with IL-6 and IL-10 detection is feasible in detecting atherosclerotic plaques in rabbits.</p>
Full text:
1
Index:
WPRIM
Main subject:
Dextrans
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Interleukin-6
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Interleukin-10
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Magnetic Resonance Angiography
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Contrast Media
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Diagnosis
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Atherosclerosis
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Plaque, Atherosclerotic
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Magnetite Nanoparticles
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article