Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses / 南方医科大学学报
Journal of Southern Medical University
; (12): 961-964, 2014.
Article
in Zh
| WPRIM
| ID: wpr-312658
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.</p><p><b>METHODS</b>The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.</p><p><b>RESULTS AND CONCLUSION</b>The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7 ± 0.3 µmol/L.</p>
Full text:
1
Index:
WPRIM
Main subject:
Antiviral Agents
/
Pharmacology
/
Physiology
/
Benzamides
/
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
/
Virus Internalization
Limits:
Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article