Progress of research on aspirin resistance and its related course of integrative medical research / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 645-648, 2010.
Article
in Zh
| WPRIM
| ID: wpr-313230
Responsible library:
WPRO
ABSTRACT
Aspirin is the most classic anti-platelet drug, plays its important role in preventing and treating cardio- and cerebro-vascular diseases for its excellent potency ratio; however, there exists individual difference in its anti-platelet effect, aspirin resistance (AR) presented in about 25%-40% of patients, which seriously influences the intervention effect of aspirin. So AR has become a clinical problem that attached more attention. In this paper, the authors put forward a new thinking for clinical studying and inventing new effective Chinese drugs on AR by means of screen out AR suffered from cardio/cerebro-vascular patients long-term received aspirin; find their gene difference sites from MtSNP to establish a foundation for AR predication and reasonable strategy formation; meantime, through platelet intervention in vitro adopting uniform design optimization method to explore the best compatibility and matching relationship of anti-platelet Chinese medicine for AR prevention and treatment, so as to fully display the multi-target intervening effects of Chinese drug-therapy.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Research Design
/
Drug Resistance
/
Platelet Aggregation Inhibitors
/
Aspirin
/
Integrative Medicine
/
Methods
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article