The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 580-582, 2006.
Article
in Zh
| WPRIM
| ID: wpr-313399
Responsible library:
WPRO
ABSTRACT
In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sI-CAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P<0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
Zh
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2006
Type:
Article