Abnormal changes of CD28 expression on CD4 + T cells in treatment-näive and highly active antiretroviral therapy-treated HIV/AIDS patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 618-621, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-313721
ABSTRACT
<p><b>OBJECTIVE</b>To study the alteration of the expression of CD28 on CD4 + T cells in HIV/AIDS patients and observe the dynamics of CD28 expression under highly active antiretroviral therapy (HAART).</p><p><b>METHODS</b>The expression of CD28 on CD4 + T cells, CD4 counts, and plasma viral load were measured by flow cytometry and bDNA assays in 278 treatment-naïve HIV/AIDS patients and 56 healthy controls. In addition, the evolution of these parameters was assessed in 59 patients who initiated HAART and were followed for 12 months in regular 3-month visits.</p><p><b>RESULTS</b>The median level of CD28 on CD4 + T cells decreased dramatically in treatment-naïve HIV-positive individuals than in HIV-negative controls (P <0.001). The expression rate of CD28 molecule was positively correlated with CD4 counts (r = 0.484, P < 0.001), and negatively correlated with plasma viral load (r = -0.300, P <0.001). In patients who had received one month of standard HAART, the level of CD28 on CD4 + T cells increased rapidly from 75.0% to 90.0% (P < 0.001). Moreover, there was a negative correlation between the median CD28 expression and the median viral load (r = - 0.829, P = 0.042).</p><p><b>CONCLUSIONS</b>The level of CD28 expression on CD4 + T cells is down-regulated in treatment-naïve HIV/AIDS patients. HAART can successfully restore the lymphocyte subsets of CD4 + CD28 + T cells. The up-regulation of CD28 expression after HAART may be closely correlated with the suppression of the viral replication.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
CD4-Positive T-Lymphocytes
/
HIV Infections
/
Follow-Up Studies
/
CD28 Antigens
/
Viral Load
/
Antiretroviral Therapy, Highly Active
/
Drug Therapy
/
Allergy and Immunology
/
Flow Cytometry
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Type:
Article
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