Morphologic observation of the regenerated nerve in reconstructed penis with sensory nerve implantation in rabbit / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 416-419, 2007.
Article
in Zh
| WPRIM
| ID: wpr-314202
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanism of sensory nerve regeneration of the reconstructed penis with sensory nerve implantation and to explore a new surgical technique to improve the postoperative sensory function in phallic reconstruction.</p><p><b>METHODS</b>Adult male New Zealand rabbits were randomly divided into experimental group (n = 20, with sensory nerve implantation) and control group (n = 20, without sensory nerve implantation), which were both performed phalloplasty with a superficial epigastric faciovascular pedicle flap. Postoperatively, the nerve regeneration process of the reconstructed penis was observed histologically.</p><p><b>RESULTS</b>In experimental group, the amount of CGRP positive nerve fibers increased markedly with the time prolonged, whereas merely a few CGRP positive fibers scattered in deep dermis 6 months later in the other group. The cutaneous sensory nerve regeneration of the reconstructed penis in experimental group shows the procedure that the myelinated axon began to exist within 3 months, thereafter the myelinated axon and unmyelinated axon were both observed under the electron microscope.</p><p><b>CONCLUSION</b>These findings show that the rabbit model of phalloplasty with sensory nerve implantation can acquire well sensory reinnervation, and bring a light to clinical application for restoration of sensory function in reconstructed penis.</p>
Full text:
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Index:
WPRIM
Main subject:
Penis
/
General Surgery
/
Surgical Flaps
/
Nerve Regeneration
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Plastic Surgery
Year:
2007
Type:
Article