Gene diagnosis of hemophilia B by multiple STR analysis / 中华血液学杂志
Chinese Journal of Hematology
; (12): 147-150, 2002.
Article
in Zh
| WPRIM
| ID: wpr-314664
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a simple, rapid genetic diagnostic system for haemophilia B.</p><p><b>METHODS</b>The polymorphisms of eight STR loci in 87 normal persons and 8 haemophilia B families were assayed by PCR and genescan, and the linkage relations were analysed.</p><p><b>RESULTS</b>Six of the eight STR loci can provide genetic information for haemophilia B, and the heterozygosity is 0.50 approximately 0.83, PIC 0.39 approximately 0.80, and DP 0.66 approximately 0.94.</p><p><b>CONCLUSION</b>Combination of multiple STR loci analysis could be effective method for genetic diagnosis of haemophilia B.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pedigree
/
Polymorphism, Genetic
/
Hemophilia B
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Diagnosis
/
Genetics
/
Genetic Carrier Screening
/
Genetic Linkage
/
Methods
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Hematology
Year:
2002
Type:
Article