Competing endogenous RNA regulation mechanism and its role in the development and progression of colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 1318-1321, 2012.
Article
in Zh
| WPRIM
| ID: wpr-314798
Responsible library:
WPRO
ABSTRACT
MicroRNAs are negative regulators of mRNA, and latest studies show that "mRNAs can also inhibit microRNAs". With these reciprocal interactions, different mRNAs with identical "microRNA binding site" cim regulate each other by competitively binding to the same microRNA pool. This is the novel competing endogenous RNA (ceRN A)regulating mechanism. The ceRN A mechanism, which is a totally new regulating mechanism , greatly expands the regulatory network across genes. It has been proved by experimental evidence that, in HCT116 colon cancer cells,KRAS and PTEN , ZEB2 and PTEN can regulate each other by ceRNA mechanism.
Full text:
1
Index:
WPRIM
Main subject:
RNA, Messenger
/
Colorectal Neoplasms
/
MicroRNAs
/
HCT116 Cells
/
PTEN Phosphohydrolase
/
Genetics
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2012
Type:
Article