Chemical constituents from stems of Brucea mollis and their cytotoxic activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2321-2324, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-315033
ABSTRACT
Ten compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as deacetylated isobrucein B (1), indaquassin X (2), cleomiscosin A (3), cleomiscosin B (4), (+)-lyoniresinol (5), (+)-epipinoresinol(6), (+)-pinoresinol (7), (+)-syringaresinol (8), 4,5-dihydroblumenol A (9) and adenosine (10) on the basis of spectroscopic data analysiS. All compounds were obtained from this plant for the first time, moreover, compound 1 was a new natural product. Compound 2 showed significant cytotoxic activities against the human cell lines HT-29, HepG2, BGC-823 and SKOV3 with IC50 values of 0.84-3.97 micromol x L(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Drug Screening Assays, Antitumor
/
Plant Extracts
/
Chemistry
/
Plant Stems
/
HT29 Cells
/
Inhibitory Concentration 50
/
Brucea
/
Cell Line, Tumor
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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