Sequential evaluation of brain lesions using functional magnetic resonance imaging in patients with Leigh syndrome / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the value of functional magnetic resonance imaging (MRI) in sequential evaluation of patients with Leigh syndrome.</p><p><b>METHODS</b>Two patients with Leigh syndrome underwent diffusion weighted imaging (DWI), perfusion weighted imaging (PWI) and proton magnetic resonance spectroscopy ((1)H-MRS).</p><p><b>RESULTS</b>The brain lesions showed hyperintensity on DWI, lactate doublet peak on MRS and hyperperfusion in the patients at baseline, and maintained a hyperintensity on DWI and hyperperfusion in the absence of lactate doublet peak on MRS at follow-up 1 year later. DWI still revealed persistent hyperintensity in the brain lesions in one patient 2 years later.</p><p><b>CONCLUSION</b>Functional MRI can sensitively highlight the characteristics of brain lesions in patients with Leigh syndrome, and can therefore be used to evaluate the sequential changes of the brain lesions.</p>