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Studies on preparation of sustained-release Shuxiong formulation, a traditional Chinese medicine compound recipe, using time-controlled release techniques / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1413-1417, 2006.
Article in Chinese | WPRIM | ID: wpr-316036
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a sustained-release formulation of traditional Chinese medicine compound recipe by adopting time-controlled release techniques.</p><p><b>METHOD</b>Shuxiong tablets were chosen as model drug. The prescription and technique of core tablets were formulated with selecting disintegrating time and swelling volume of core tablets in water as index. The time-controlled release tablets were prepared by adopting press-coated techniques, using PEG6000, HCO and EVA as coating materials. The influences of compositions, preparation process and dissolution conditions in vitro on the lag time (T(lag)) of drug release were investigated.</p><p><b>RESULT</b>The composition of core tablets was as follow 30% of drug, 50% MCC and 20% CMS-Na. The T(lag) of time-controlled release tablets was altered remarkably by PEG6000 content of the outer layer, the amount of outer layer and hardness of tablet. The viscosity of dissolution media and basket rotation had less influence on the T(lag) but more on rate of drug release.</p><p><b>CONCLUSION</b>The core tablets pressed with the optimized composition had preferable swelling and disintegrating properties. The shuxiong sustained-release formulations which contained core tablet and two kinds of time-controlled release tablets with 3 h and 6 h of T(lag) could release drug successively at 0 h, 3 h and 6 h in vitro. The technique made it possible that various components with extremely different physicochemical properties in these preparations could release synchronously.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Polyethylene Glycols / Tablets / Castor Oil / Drugs, Chinese Herbal / Chemistry / Povidone / Ligusticum / Carthamus tinctorius / Delayed-Action Preparations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Polyethylene Glycols / Tablets / Castor Oil / Drugs, Chinese Herbal / Chemistry / Povidone / Ligusticum / Carthamus tinctorius / Delayed-Action Preparations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2006 Type: Article