Value assessment of high-risk HPV test and TCT in the screening of cervical carcinoma / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 273-276, 2013.
Article
in Zh
| WPRIM
| ID: wpr-318044
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To estimate the status of coincidence of high-risk HPV (HR-HPV) test and thinprep cytology test(TCT) with biopsy histopathological diagnosis. And explore the diagnostic value in the cervical cancer and precancerous lesions by combination of these two methods.</p><p><b>METHODS</b>Retrospective analysis cases with the positive cytological diagnosis. Acrodding to the principle of voluntariness and informed consent, 3197 cases were selected and further investigated by high-risk human papillomavirus testing and biopsy histopathological diagnosis. We had a comparative analysis to the coincidence of TCT, high-risk HPV-DNA test and biopsy histopathological diagnosis.</p><p><b>RESULTS</b>Among 3197 cases, 58.6% cases with chronic inflammation, 26.1% cases with condyloma or CIN I, 14.1% cases with CIN II-III, and 1.2% cases with invasive cervical carcinoma. Compared with pathological biopsy, the coincident rate of the diagnosis of TCT cytology and histopathology were 21.2% (ASC-US), 28.6% (ASC-H), 39.6% (LSIL), 56.2% (HSIL) and 72.4% (cervical carcinoma), respectively. Among cases of positive TCT diagnosis, Compared HR-HPV test and histopathological diagnosis, infection rate of HR-HPV increases significantly with increasing pathological grade (chi2 = 292.354, P = 0.000 < 0.05). As the TCT diagnostic level increases, the positive rate of HR-HPV marked grows (chi2 = 144.113, P = 0.000 < 0.05).</p><p><b>CONCLUSION</b>TCT can reduce the incidence of cancer effectively. But lower sensitivity in the low-grade cervical lesions may cause missed diagnosis. Combined TCT and HR-HPV test will improve the detection rate of cervical lesions; it is an ideal method to screening cervical cancer.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Vaginal Smears
/
Virology
/
Carcinoma
/
Uterine Cervical Neoplasms
/
Retrospective Studies
/
Cytological Techniques
/
Diagnosis
/
Alphapapillomavirus
/
Early Detection of Cancer
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Screening_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2013
Type:
Article