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Optimization of extraction process of Chrysanthemi Flos by multi-index orthogonal experiment / 中国中药杂志
Zhongguo Zhong Yao Za Zhi ; (24): 821-824, 2013.
Article in Zh | WPRIM | ID: wpr-318637
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore quantitative assessment indicators of Chrysanthemi Flos, and optimize the extraction process of Chrysanthemi Flos through orthogonal experimental design.</p><p><b>METHOD</b>The concentration of ethanol, amount of ethanol, extraction time and extraction frequency were selected as factors in the L9 (3(4)) orthogonal experiment. A comprehensive assessment was conducted with the peak area of the eight major common peaks in the fingerprint of Chrysanthemi Flos as the indicators.</p><p><b>RESULT</b>The optimum extraction process was selected as follows: using ultrasonic extraction method, adding 30-fold ethanol with 80% concentration, extracting for 2 times for extraction, 40 min for each time.</p><p><b>CONCLUSION</b>The optimized extraction process is reliable, with controllable assessment indicators, which is significant to the standardization of the extraction process and quality control of Chrysanthemi Flos preparations.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Quality Control / Solubility / Time Factors / Drugs, Chinese Herbal / Chemistry / Reproducibility of Results / Chrysanthemum / Ethanol / Chemical Fractionation / Hot Temperature Language: Zh Journal: Zhongguo Zhong Yao Za Zhi Year: 2013 Type: Article
Full text: 1 Index: WPRIM Main subject: Quality Control / Solubility / Time Factors / Drugs, Chinese Herbal / Chemistry / Reproducibility of Results / Chrysanthemum / Ethanol / Chemical Fractionation / Hot Temperature Language: Zh Journal: Zhongguo Zhong Yao Za Zhi Year: 2013 Type: Article