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Research advances on hydrogen therapy in nervous system diseases / 浙江大学学报·医学版
Article in Zh | WPRIM | ID: wpr-319845
Responsible library: WPRO
ABSTRACT
Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pharmacology / Physiology / Hydroxyl Radical / Oxidative Stress / Peroxynitrous Acid / Drug Therapy / Hydrogen / Metabolism / Nervous System / Nervous System Diseases Limits: Humans Language: Zh Journal: Zhejiang Daxue xuebao. Yixue ban Year: 2010 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Physiology / Hydroxyl Radical / Oxidative Stress / Peroxynitrous Acid / Drug Therapy / Hydrogen / Metabolism / Nervous System / Nervous System Diseases Limits: Humans Language: Zh Journal: Zhejiang Daxue xuebao. Yixue ban Year: 2010 Type: Article