Role of membrane-bound human leukocyte antigen G in inducing immune tolerance after allogeneic hematopoietic stem cell transplantation / 南方医科大学学报
Journal of Southern Medical University
; (12): 2202-2203, 2008.
Article
in Zh
| WPRIM
| ID: wpr-321729
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the role of human leukocyte antigen G (HLA-G) in the better effect of allogenetic bone marrow transplantation than that of peripheral blood stem cell transplantation.</p><p><b>METHODS</b>Flow cytometry was used to detect the expression of membrane-bound HLA-G (mHLA-G) on donor peripheral blood (PBC) or bone marrow (BM) mononuclear cells. The levels of soluble HLA-G (sHLA-G) in the plasma and bone marrow fluid were determined using enzyme-linked immunosorbent assay (ELISA) before and after granulocyte colony-stimulating factor (G-CSF) mobilization.</p><p><b>RESULTS</b>The mean levels of mHLA-G after G-CSF mobilization in the PBC and BM were significantly higher than that before G-CSF mobilization (P=0.001 and 0.000), but the plasma levels of sHLA-G showed no significant changes after the mobilization (P=0.279). The mean levels of sHLA-G in the BM fluid significantly increased (P=0.002) to a level higher than that in the PBC after G-CSF mobilization (P=0.004).</p><p><b>CONCLUSION</b>HLA-G plays an important role in immune tolerance after hematopoietic stem cell transplantation with G-CSF mobilization.</p>
Full text:
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Index:
WPRIM
Main subject:
Pharmacology
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Histocompatibility Antigens Class I
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Granulocyte Colony-Stimulating Factor
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Bone Marrow Transplantation
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Hematopoietic Stem Cell Transplantation
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Hematopoietic Stem Cell Mobilization
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Allergy and Immunology
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HLA-G Antigens
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HLA Antigens
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Immune Tolerance
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article