Coumarins of Anemone raddeana Regel and their biological activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 206-209, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323057
ABSTRACT
To study the coumarins of Anemone raddeana Regel, the compounds were separated by silica gel column chromatography and HPLC. Their structures were identified by their physicochemical property and spectral analysis. Two new compounds were isolated and identified as 4, 7-dimethoxyl-5-methyl-6-hydroxy coumarin (1) and 4, 7-dimethoxyl-5-formyl-6-hydroxycoumarin (2). The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). In addition, the two compounds had inhibitory effect against human leukocyte elastase (HLE).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Molecular Structure
/
Transcriptional Activation
/
Chemistry
/
Receptors, Retinoic Acid
/
Leukocyte Elastase
/
Inhibitory Concentration 50
/
Coumarins
/
Rhizome
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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