Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as anti-cancer agents / 药学学报
Acta Pharmaceutica Sinica
; (12): 200-205, 2012.
Article
in Zh
| WPRIM
| ID: wpr-323058
Responsible library:
WPRO
ABSTRACT
A series of novel N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their anti-cancer activities. Among these analogs, compound 9a exhibited the potential anti-cancer activities on HepG2 and HCT116 cells with IC50 values of 2.52 and 1.99 microg x mL(-1), respectively. Cell cycle was blocked at S phase of HepG2 cells treated with 9a by flow cytometry detection. Our results provided a basis for the development of a new series of anti-cancer candidates.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Molecular Structure
/
Cell Cycle
/
Chemistry
/
Inhibitory Concentration 50
/
HCT116 Cells
/
Cell Proliferation
/
Hep G2 Cells
/
Isoquinolines
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article