Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 194-199, 2012.
Article
in Zh
| WPRIM
| ID: wpr-323059
Responsible library:
WPRO
ABSTRACT
To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.
Full text:
1
Index:
WPRIM
Main subject:
Structure-Activity Relationship
/
Molecular Structure
/
Random Allocation
/
4-Aminopyridine
/
Chemistry
/
Therapeutic Uses
/
Drug Therapy
/
Epilepsy
/
Amides
/
Gamma-Aminobutyric Acid
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article