Association between polymorphism of CYP17 gene and serum hormone concentrations in aged men / 中华男科学杂志
National Journal of Andrology
; (12): 442-444, 2005.
Article
in Zh
| WPRIM
| ID: wpr-323339
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men.</p><p><b>METHODS</b>Eighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter region was investigated by PCR using DNA from the men's peripheral blood lymphocytes. A new recognition site was created for the restriction enzyme MspA1 I by transition (T --> C) in the risk allele (A2). Three genotypes A1/A1, A1/A2, A2/A2 were established, serum sex-hormone levels measured, and mean hormone concentration evaluated in each genotype and age group.</p><p><b>RESULTS</b>No evidence was found that the testosterone (T) level, estrogen (E2) level and T/E2 ratio were associated with the genotype of CYP17 gene. There was no significant difference in T and E2 levels between the two groups, but there was a significant increase in the T/E2 ratio (P < 0.05).</p><p><b>CONCLUSION</b>A2 allele does not increase sex hormone levels in aged men, but the T/E, ratio was higher in the > 66.7 group than in the < 66.7 group. This may be closely associated with the mechanism of benign prostate hyperplasia and prostate cancer in aged men.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Testosterone
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Blood
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Steroid 17-alpha-Hydroxylase
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Polymerase Chain Reaction
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Promoter Regions, Genetic
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Estradiol
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Genetics
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Genotype
Limits:
Adult
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Aged
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Aged80
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Humans
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Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2005
Type:
Article