Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus / 대한마취과학회지
Korean Journal of Anesthesiology
; : 794-801, 2001.
Article
in Ko
| WPRIM
| ID: wpr-32416
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70) and the acid-fuchsin stain.METHODS:
Administration of etomidate (20 mg/kg, I.P.) was performed in sequence; first being just one hour after a KA (10 mg/kg, I.P.) injection, then three more times at one hour intervals. Neuronal damages in the hippocampus were evaluated by using the acid-fuchsin stain to detect cell death and HSP-70 induction as an index of cell injury at 24 h after the administration of KA.RESULTS:
HSP-70 induction and acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after a KA injection but significantly decreased by an injection of etomidate (P < 0.01).CONCLUSIONS:
These results suggest that the etomidate has a potential effect on the protection of neurons against KA-induced neurotoxicity.Key words
Full text:
1
Index:
WPRIM
Main subject:
Rosaniline Dyes
/
Shock
/
Cell Death
/
Neuroprotective Agents
/
Etomidate
/
Hot Temperature
/
Hippocampus
/
Kainic Acid
/
Neurons
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2001
Type:
Article