Relationships among apolipoprotein A1 gene polymorphisms, lipid levels and coronary atherosclerosis disease / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 665-668, 2003.
Article
in En
| WPRIM
| ID: wpr-324439
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship among -75 bp/+83 bp polymorphism in apolipoprotein A1 (apo A1) gene, lipids levels and the occurrence of coronary atherosclerosis disease (CAD).</p><p><b>METHODS</b>We determined distributions of two MspI polymorphisms of the apo A1 gene at -75 bp and +83 bp, and blood lipids levels among 137 Chinese patients (92 with CAD and 45 in the control group) in relation to circulating lipids and coronary angiography.</p><p><b>RESULTS</b>The demographic information for 137 subjects showed that subjects with CAD tended to have more unfavorable lipoprotein variables. Genotype distributions at both sites were different between the CAD and control groups. Furthermore, the control group had higher M1-/M2- frequencies than the CAD group (M1 P < 0.005; M2 P < 0.05) and the "M1-" (A) and "M2-" alleles were associated with increased high-density lipoprotein cholesterol (HDL-C) (M1- P < 0.0001; M2- P < 0.05) and apo A1 (M1- P < 0.0001; M2- P < 0.05) levels. "M1-" and "M2-" were significantly negatively correlated with CAD (P < 0.01 and P < 0.05, respectively).</p><p><b>CONCLUSIONS</b>Our results suggest that changes from G to A at the -75 bp site and from C to T or G to A at the +83 bp site do increase circulating levels of apo A1 and HDL-C. And those individuals with these changes are likely to have a lower risk of developing CAD.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Blood
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Coronary Artery Disease
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Case-Control Studies
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Apolipoprotein A-I
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Genetics
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Lipids
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Cholesterol, HDL
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Female
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Humans
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Male
Language:
En
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article