Association of XPC and XPG polymorphisms with the risk of hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 271-275, 2010.
Article
in Zh
| WPRIM
| ID: wpr-326385
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the polymorphism of DNA repair genes XPC (Ala499Val and Lys939Gln) and XPG (His1104Asp) is associated with the susceptibility to hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>A hospital-based case-control study was conducted in 500 cases with HCC and 507 controls. Genotypes of XPC and XPG were determined by real-time polymerase chain reaction with the TaqMan MGB probe.</p><p><b>RESULTS</b>Compared to the CC genotype, the CT genotype and the TT genotype of XPC Ala499Val were not associated with the susceptibility to HCC (adjusted OR = 1.34, 95% CI 0.85-2.12; adjusted OR = 1.30, 95% CI 0.68-2.51, respectively). Compared to the AA genotype, the AC genotype and the CC genotype of Lys939Gln were not associated with the susceptibility to HCC (adjusted OR = 1.20, 95% CI 0.78-1.85; adjusted OR = 1.81, 95% CI 0.88-3.73, respectively). Compared to the CC genotype, the CG genotype and the GG genotype of XPG His1104Asp were not associated with the susceptibility to HCC (adjusted OR = 0.85, 95% CI 0.56-1.27; adjusted OR = 1.12, 95% CI 0.67-1.87, respectively) However, the stratified analysis revealed that the females with the AC+CC genotype of XPC Lys939Gln had increased risk of HCC compared to those with AA genotype (OR = 2.17, 95% CI 1.01-4.64).</p><p><b>CONCLUSION</b>Our results suggest that XPC and XPG polymorphisms do not independently affect on the susceptibility to HCC, but the joint effect of C allele of XPC Lys939Gln and female may modify the risk of HCC.</p>
Full text:
1
Index:
WPRIM
Main subject:
Transcription Factors
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Nuclear Proteins
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Case-Control Studies
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Carcinoma, Hepatocellular
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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DNA-Binding Proteins
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DNA Repair
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Endonucleases
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Genetics
Type of study:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2010
Type:
Article