Dynamics of T lymphocyte subsets in SARS patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 525-528, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-327045
ABSTRACT
<p><b>OBJECTIVE</b>To study dynamics of T lymphocyte subsets in severe acute respiratory syndrome (SARS).</p><p><b>METHODS</b>Sequential anti-coagulated blood samples were collected from 46 cases of SARS patients during the 1st week, the 2nd week, the 3rd-5th week and the 8th-12th week after the infection. T lymphocyte subsets including CD3+CD4+ cells, CD3+CD8+ cells, naive CD4+ cells (CD4+CD45RA+CD62L+) and activated CD8+ cells (CD8+CD38+) were detected by 3-color flow cytometry. Fifty-six normal healthy blood donors were also detected as normal controls.</p><p><b>RESULTS</b>Compared with the results of normal controls, both of the percentages of CD4+ cells and CD8+ cells of SARS patients were in normal levels during the 1st week, but the cell counts decreased significantly to (306 +/- 140)/mm3 and (270 +/- 143)/mm3, respectively. The cell count of naive CD4+ subset also remarkably decreased to (96 +/- 49)/mm3, and the percentage of CD8+CD38+ subset was higher than that of normal controls [(59.3 +/- 12.6)% vs (44.9 +/- 12.5)%]. During the 3rd-5th week, the CD8+ cell count and the percentage of CD8+CD38+ subset reached normal values, which were (581 +/- 356)/mm3 and (40.1 +/- 17.6)%, respectively. During the 8th-12th week, the cell counts of CD4+ cell [(578 +/- 193)/mm3] and naive CD4+ subset [(176 +/- 64)/mm3] were still less than those of normal controls, while compared with those of the 1st week, the increments were remarkable.</p><p><b>CONCLUSIONS</b>T lymphocytes of SARS patients decreased dramatically but could be obviously resumed in a short time. It will take more than 8-12 weeks for CD4+ cell and naive CD4+ subset to reach to normal levels.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
CD4-Positive T-Lymphocytes
/
T-Lymphocyte Subsets
/
CD4-CD8 Ratio
/
CD4 Lymphocyte Count
/
Severe Acute Respiratory Syndrome
/
Allergy and Immunology
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2003
Type:
Article
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